Why the vaccine failure in dogs?

Some dogs after vaccination or infection of this should be within the scope of immune diseases. Distressed owners to ask: "vaccine is not covered?" Some people even regret it with a dog vaccination, therefore, with all the wrong guess.
Extensive research and clinical application of results show that vaccination is indeed a good way to prevent dog diseases. However, the vaccine protection rate of 90% to 95%, not a hundred percent foolproof. Many factors affect the effectiveness of the vaccine to master this knowledge will help to further improve vaccine protection.

1. Lack of antibodies. After vaccination can prevent disease, depending on whether the vaccine produced antibodies to stimulate the dog, as well as the amount of antibodies (with titers indicated). Is generally believed that serum antibody titers of more than 10 international units per milliliter of time in order to prevent infectious diseases. About 30% of dogs 1 month after vaccination, antibodies appear to complete a full month after injection of an antibody to reach the highest level. Therefore, before the completion of all injections, antibody titers did not produce or relatively low, there is still the possibility of infection. During this time, the dogs were still closely by other preventive measures.
According to research, dogs on the level of antibody titer vaccines can be divided into four groups:
1. Non-response group, accounting for 5% of the number of injections. Dogs not respond to the vaccine most probably mainly due to genetic factors. Vaccine's ability to produce antibodies by the Ⅱ type of major histocompatibility complex (MHC) control, are autosomal dominant.
2. Low response group. Produced after vaccination serum antibody titers of less than 10 international units per milliliter, and about 10% of the number of injections. This is genetic, older, obesity, immune suppression, immune tolerance and other factors.
3. In the response team. After vaccination serum antibody titers produced per ml of 10 ~ 100 international units, accounting for about 65% of the number of injections.
4. High reaction group. Serum antibody titers greater than 100 international units per milliliter, and about 20% of the number of injections. Non-response group and the low response group is still possible for dogs to infectious diseases after vaccination.

二. Have been infected with the virus. Even if the vaccination is given before the dog was examined by the normal indicators, there at the onset of the incubation period may not come out to inspect. The vaccine produced antibodies in the blood the virus is only effective in the cells, the virus has entered is invalid. Therefore, if vaccination had been infected with a virus before, then the vaccine is invalid.
三. Save inappropriate. The vaccine should not be frozen, frozen to destroy its structure. 37 ℃ to save not more than 1 month, 4 ℃ to save not more than 1 year. Save time, too long, the immune effect will be reduced. Household refrigerator freezer can be saved.
四. Improper use. The vaccine should not be injected in the buttocks. Hip fat tissue, immune cells, less active after injection produced a low antibody titers, antibody decline in speed.
五. Variation of the virus. Even if the vaccine produced a high titer of antibodies, a few dogs may still become ill. This is because the virus can mutate, while the existing vaccines against the normal virus. If the virus mutated surface antigen, vaccine, unfortunately, dogs infected with the virus of this mutation, it is still possible to get sick.
六. Of poor health - such as the parasite is not cleared, there is high fever, etc., resulting in immunization failure.
7. Injection timing was not right - mostly early, still a lot of time in the transitional antibody injection, part of the antigen was offset, of course, can produce the function is significantly impaired. Or follow the doctor asked the reinforcement 11 has not append more than one year, of course, there are still likely to be infected, because the vaccine effectiveness can only be maintained for one year.
8. The individual dog's own immune system is not perfect
九. There are other being the use of certain drugs

Undoubtedly, the immunity is the basic guarantee of a healthy dog, but also a fundamental obligation of each dog owners. Neither of the view that all that is needed to fight a vaccine, but should not have won because the immunization is still infectious, it simply does not vaccinating dogs. After the completion of the vaccine should be carried out full inspections. If did not produce antibodies, but also to re-vaccination. In order to improve the chances of a successful immunization, some experts believe that zinc supplementation, IL-2 or the thymus is known is likely to increase antibody titers, we might try to do.